Dr Ben Caplin and Professor Neil Pearce
Uncovering the cause of the kidney disease epidemic affecting agricultural communities in Central America
Dr Caplin and Professor Pearce have been running a very successful project on ‘Occupational kidney disease in Pacific Coast Central America’ for the last three years, and this new grant of £228,426 was awarded by the Trustees to continue the research for a further three years from 2018. Dr Caplin can be contact on firstname.lastname@example.org and Professor Pearce can be contacted on email@example.com
Professor Anthony Seaton
Professor Seaton is well known to the Foundation, from the University of Aberdeen, the Institute of Occupational Medicine (IOM) in Edinburgh, and also through his connection with the St Mary’s Cathedral Workshop in Edinburgh. During the period Professor Seaton was leading the IOM, the Coal Board indicated they would be withdrawing support for the IOM, and the Foundation awarded a grant over a period of 5 years to help them continue with their work whilst building up income from sources other than the Coal Board.
Professor Seaton has now written a book entitled “Farewell King Coal: from industrial triumph to climatic disaster”, telling the tale of the rise of coal in the industrial revolution and of its consequences for the miners, by-product workers and the rest of human-kind through air pollution and climate change. It is written for general readers and assumes no scientific knowledge.
The Trustees felt this was a very interesting and valuable record and agreed to provide sponsorship to help launch the book when it is published in October 2018.
Professor Paul Cullinan and Dr Meinir Jones
“Proof of principle study to determine whether we can identify genetically modified enzymes in dough ‘improved’ mix using mass spectrometry” A grant of £8,000 for this research over a six month period was agreed at the November 2017 Trustees’ Meeting. Professor Cullinan can be contacted on firstname.lastname@example.org and Dr Jones on email@example.com.
Dr Johanna Feary
The Trustees agreed to provide a one year Fellowship starting in January 2018 to Dr Feary for work on Hypersensitivity Pneumonitis. Dr Feary can be contacted on firstname.lastname@example.org
Professor Karen Walker-Bone et al - What are the modifiable factors that would enable people to work to older ages in good health and comfort?
At the May 2017 Trustees’ Meeting, Professor Walker-Bone was awarded a grant of £125,000 over three years for this study, and work started in July 2017. Her contact details are email@example.com
Dr Rodger Duffin and Dr Craig Poland - Identifying qualitative thresholds of toxicity within key structure activity relationships in inhalation particle toxicology for the improvement of hazard identification and risk assessment
Dr Duffin and Dr Poland have both received funding from the Foundation previously, and the Trustees agreed to support this two year study at a cost of £262,000. Work started in March 2017. Dr Duffin can be contacted on firstname.lastname@example.org, and Dr Poland can be contacted on email@example.com
Professor John Barbur and Dr Marisa Rodriguez-Carmona - Proposal to develop and validate a CAD screener test for use in visually-demanding occupational and primary healthcare
Professor Barbur and Dr Marisa Rodrigue-Carmona have been funded previously by the Foundation, see below, and the Trustees agreed to further funding over two years for this new project. Work will start in 2017. Professor Barbur can be contacted on firstname.lastname@example.org
Professor Paul Cullinan - One year funding request to support Ms Silvia Colicino
Silvia has been working within Imperial College as a medical statistician for three years, and has been supported by funds from the MRC STELAR project, playing an important role in the project. This funding runs out at the end of December 2016, and the Trustees agreed to fund Silvia for a further year to the end of 2017 to continue the work.
Dr Carla Guerriero - Workshop on the methodology of cost-benefit analysis of environmental health interventions: and interdisciplinary approach
Dr Guerriero was a former Colt Foundation PhD student, and since completing, Carla has presented a numerous conferences, had several papers published, and her work has been covered in the Italian press. The Trustees agreed to support this Workshop with a grant of £8,000 to cover speakers expenses and other costs. The Workshop will be held in London in 2017.
MSc in Human and Applied Physiology
The Foundation has been supporting individual students on this course since 1981 and decided in 1992 that this support would be formalised with an initial three year grant awarded to King's College London for the benefit of the students undertaking the course. Our founding Scientific Adviser, Professor David Denison, lectured on this course in the early days, and remained a strong supporter right up until his death in 2014. The grant has been renewed every three years since 1992. At the May 2016 Meeting, the Trustees agreed unanimously that this is an excellent course and extended this funding for a further three years at the rate of £20,000 p.a. The Programme Director is responsible for the selection of students, and decides on how the Colt funding will be allocated. A prize is awarded each year for the best dissertation, and this prize will be known in future as The Colt Foundation David Denison Memorial Prize. Full details on the MSc course can be obtained from the Programme Director, Dr James Clark on email@example.com
Ms Alison Connelly - PhD Student at National University of Ireland, Galway
Having been awarded a three year studentship to start her studies, the Irish Higher Education Authority then put in a requirement for students to register for a four year course, leaving Alison without funding for her fourth year. Her studies are in Biological Monitoring for Pesticide Exposures. The Trustees felt it was an important area of research, with practical as well as training value, and agreed that we would support the final fourth year of study to ensure she was able to complete.
Dr Giovanni Leonardi, Public Health England
Association or Causation in Miasmas and Mixtures: current reflections on Bradford Hill’s 1965 contribution to Public Health
Dr Leonardi helped to organise a scientific symposium marking 50 year since Bradford Hill published his still widely used paper ‘Environment and Disease: Association or Causation?’ This was held at the Royal Society of Medicine in London on 13th and 14th October 2016. The Trustees agreed to a grant of £8,000 to cover the travel costs of the speakers. Dr Leonardi can be contacted on firstname.lastname@example.org
Young Investigators’ Colloquium – Nanotoxicology 2016
Dr Craig Poland and Dr Martin Clift helped to organise a Young Investigators’ Colloquium at the 8th International Nanotoxicology conference in Boston, USA. The Trustees agreed to a grant to provide a first and second prize for two young scientists to recognise outstanding effort and encourage participation. The prizes were presented as ‘The Colt Foundation Best Presentation Award’. Craig can be contacted on email@example.com and Martin can be contacted on firstname.lastname@example.org
The winner of the first prize for the best presentation was Mr Leon Newman, a PhD student from the University of Manchester. The second prize was won by Ms Savvina Chortarea from the Adolphe Merkle Institute in Fribourg, Switzerland.
Royal Society of Medicine - United Services Section
Following a meeting at the Institute of Naval Medicine with Surgeon Commodore Jim Sykes, it was agreed that the Foundation would sponsor the United Services Section of the RSM annual Research Prize from 2007. The Section Meeting is devoted to presentations by two military doctors in training from each of the three services. Abstracts are submitted to the Defence Postgraduate Dean during the year, and six speakers are selected. The Foundation agreed to award a prize to the speaker who gave the best presentation, with further prizes for the remaining speakers. Additional sponsorship was offered in early 2012 to cover a full research day in addition to the prizes, and this event is now known as the Colt Foundation Military Medicine Research Day. The meeting takes place in December each year at the RSM. At the Trustees' Meeting in May 2015, it was agreed to continue to support the Colt Foundation Military Medicine Research Day for a further three years.
University of Southampton, Institute of Sound and Vibration
A project entitled 'Adverse effects of airborne ultrasound in public spaces' to be led by Dr Ben Lineton was discussed by the Trustees at the Meeting in May 2015. The work concerns acoustic waves at frequencies above 20kHz that are too high for most adults to perceive. There is no regulation covering such frequencies, although some people have complained of various symptoms which they attribute to sensitivity to ultrasonic exposures in public spaces. The Trustees agreed to fund this study which will start in July 2015. Dr Lineton can be contacted on email@example.com
University of Edinburgh
A further application for funding submitted by Dr Duffin was discussed at the Trustees' Meeting in November 2014, and a grant of £300,000 over three years was awarded for research entitled 'The fate of nanoparticle translocation from the lungs to the vasculature'. Work on this new project will start in April 2015. Dr Duffin can be contacted on firstname.lastname@example.org
The Foundation has a history of supporting important and relevant conferences and seminars, and the Trustees have agreed to provide underwriting costs to enable the initial planning of the 26th International Symposium on Epidemiology in Occupational Health to start in Edinburgh. Further details can be obtained from Professor Damien McElvenny on email@example.com
Queen Mary University of London
The initial project funded in 2013 is coming to a successful conclusion, and Reetika Suri, the PhD student working on the project, was awarded her PhD in December 2014. An application for a one-year postdoctoral Fellowship for Dr Suri was requested by Professor Grigg in November 2014, and the Trustees agreed a grant for the project 'Mechanisms underlying increased vulnerability to pneumococcal pnemonia following exposure to welding fume'. Work is expected to start in mid-2015. Professor Grigg can be contacted on firstname.lastname@example.org and Dr Suri can be contacted on email@example.com
London School of Hygiene & Tropical Medicine/UCL
In July 2014 a grant of £210,204 was awarded to Professor Neil Pearce and Dr Ben Caplin for a study into 'Occupational kidney disease in Pacific Coast Central America'. Over the last 15 years there has been an enormous increase in the prevalence of chronic kidney disease of unknown cause in this region, particularly amongst young male adults. The co-localisation of the epidemic to areas with intensive agricultural industry, specifically sugarcane, indicate that it is likely that there is an occupational cause of the disease. The findings will be of importance further afield in other countries with similar climates and exposure to potential toxins e.g. Sri Lanka. Work started in October 2014 and will continue until early 2018. Professor Pearce can be contacted on firstname.lastname@example.org and Dr Caplin on email@example.com
Imperial College London
The Trustees have agreed to support the MSc Environmental Technology course over the next three years by offering a prize for the student who submits the best dissertation in the field of occupational and/or environmental health.
University of Edinburgh
As shown below, a grant of £207,142 was awarded to the University of Edinburgh in November 2011 for research to be carried out by Dr Rodger Duffin, Dr Nick Mills and Dr Jen Raftis entitled "Translocation and systemic distribution of inhaled gold nanoparticles", and work started in January 2011. The most challenging study of the project will address the question "How does pulmonary inflammation influence translocation of gold nanoparticles?" To answer this question, the team will undertake inhalation studies in healthy volunteers, and these studies are conducted in a unique and purpose built mobile human exposure facility, which is maintained by collaborators from the Dutch National Institute of Public Health. The final exposure study had to be deferred to accommodate the collaborator's competing projects, and to ensure that Dr Jen Raftis was retained to complete this programme, the Trustees agreed in December 2013 to a six-month extension to the project with a grant to cover her salary costs during this additional period.
Imperial College London, Professor Paolo Vineis
At the December 2013 Meeting of the Trustees, it was agreed that subject to a satisfactory meeting with Professor Vineis and members of the research team at Imperial College, the Foundation would award a grant of £106,010 for research entitled "Do we neeed to reduce threshold limits for air pollutants? An epidemiological study on epigenetic pathways leading to lung cancer". A meeting took place with Professor Vineis and his team in early February, and the funding was confirmed. Work will start shortly. Professor Vineis can be contacted on firstname.lastname@example.org
University of Edinburgh, Dr Amanda Hunter
Dr Hunter is a clinical research fellow and specialty registrar in cardiology at the University of Edinburgh, who is currently out of training and undertaking research. The Trustees have agreed to pay her fees to enable her to complete her PhD.
King's College London
MSc in Human and Applied Physiology
The Foundation has been supporting individual students on this course since 1981 and decided in 1992 that this support would be formalised with an initial three year grant awarded to King's College London for the benefit of the students undertaking the course. The grant has been renewed every three years since that time. The Programme Director is responsible for the selection of students, and decides on how the Colt funding will be allocated. At the July 2013 Meeting, the Trustees agreed unanimously that this is an excellent course and extended this funding for a further three years at the rate of £20,000 p.a.
7th UK & Ireland Occupational and Environmental Epidemiology Meeting 2013
The Trustees were approached by Professor Damien McElvenny, who was the Chair of the 2013 Meeeting, for support for this meeting which took place on 13th March 2013 in Edinburgh. The Trustees agreed to offer underwriting costs to enable the planning process to start.
Queen Mary University of London
At the November 2012 Trustees' Meeting, it was agreed to fund a study led by Professor Jonathan Grigg, with Professor Jerry Brown from UCL, entitled "Identification of the mechanism for the association between pneumococcal pneumonia and exposure to welding fumes". Work started in early 2013 and is expected to run for eighteen months at a cost of £97,190. Professor Grigg can be contacted on email@example.com and Professor Brown on firstname.lastname@example.org.
Inhaled Particles XI (IPXI) 2013
The Trustees agreed to support this meeting, to be held in Nottingham 23rd - 25th September 2013 http://www.inhaled particles.org/ with funding for a Colt Foundation Lecture which was a valedictory lecture by Professor Ken Donaldson. In addition, there was a Colt Foundation Prize for the Best Young Scientist based on posters and spoken presentations, and assistance with travelling expenses for the Keynote Speakers. From a large and impressive entry, judged by the independent Scientific Panel, the Best Young Scientist Prize was won by Dr Jen Raftis, who is also working on the Colt-funded project at the University of Edinburgh, as shown below.
Royal Society of Medicine - United Services Section
Following a meeting at the Institute of Naval Medicine with Surgeon Commodore Jim Sykes, it was agreed that the Foundation would sponsor the United Services Section of the RSM annual Research Prize from 2007. The Section Meeting is devoted to presentations by two military doctors in training from each of the three services. Abstracts are submitted to the Defence Postgraduate Dean during the year, and six speakers are selected. The Foundation agreed to award a prize to the speaker who gave the best presentation, with further prizes for the remaining speakers. Additional sponsorship was offered in early 2012 to cover a full research day in addition to the prizes, and this event is now known as the Colt Foundation Military Medicine Research Day. The meeting takes place in December each year at the RSM.
University of Edinburgh
A grant of £207,142 was awarded to the University of Edinburgh in November 2011 for research to be carried out by Dr Rodger Duffin, Dr Nick Mills and Dr Jen Raftis entitled "Translocation and systemic distribution of inhaled gold nanoparticles". Work started in January 2012 and Jen Raftis can be contacted on email@example.com.
University of Oxford
The Trustees agreed to fund a study entitled "Translating recent advances in human physiology and genetics into improvements in health of miners at high altitudes in the Andes". The grant is for £191,732 and the work is expected to take two years. Professor Peter Robbins is leading the study based in Oxford, with Professor Fabiola Leon-Velarde in Peru, and Professor Robbins can be contacted on firstname.lastname@example.org
Deafness Research UK/University of Manchester
The Trustees awarded a grant of £134,830 over two years to Professor Chris Plack and Dr Kathryn Hopkins at the School of Psychological Sciences at the University of Manchester for research into detecting the early effects of occupational noise damage to hearing. The work started in early 2012. Professor Plack can be contacted on email@example.com
The Institute of Occupational Medicine (IOM) Edinburgh
Dr John Cherrie, working with Professor Damien McElvenny and Dr Martie van Tongeren, will be looking at "The mortality of workers with occupational lead exposure". The team was awarded a grant of £79,899 to cover this study. The work started in September 2011. Dr Cherrie can be contacted on firstname.lastname@example.org. Professor McElvenny can be contacted on email@example.com
University of Manchester
A new grant was awarded to Professor Raymond Agius for a two year study entitled "Further development, evaluation and dissemination of a model to predict the asthmagenicity of chemicals". Work started in early 2011, in collaboration with Dr Martin Seed from Manchester, and also Dr James Jarvis from the University of Edinburgh. Dr Jarvis was a previous Colt Foundation PhD student in Edinburgh. Professor Agius can be contacted on
Edinburgh Napier University
The Trustees agreed to fund a three year study at Napier University, led by Professor Vicki Stone with Dr David Brown and Dr Keith Guy (all Napier), and Professor Ken Donaldson and Dr Rodger Duffin (University of Edinburgh) entitled "The role of nanoparticle-protein interactions in determining the toxic consequences of nanoparticle exposure" at a cost of £287,282. The work started in 2009. Professor Stone and her team moved to Heriot-Watt University at the end of 2010, and the work was completed at Heriot-Watt during 2012. Professor Stone can be contacted on firstname.lastname@example.org and Professor Donaldson on email@example.com.
University College London (UCL) Centre for Sexual Health and HIV Research
A grant of £89,491 over eighteen months was agreed for work entitled "The impact of HIV/AIDS and antiretroviral therapy on mortality in South African platinum miners: 1992 - 2008". This work was led by Dr Pam Sonnenberg, who has previously been supported with a Colt Foundation PhD Fellowship, and also during her previous work in South Africa while based at the London School of Hygiene and Tropical Medicine. The final report was submitted in early 2011. Pam can be contacted on PSonnenberg@gum.ucl.ac.uk
London School of Hygiene & Tropical Medicine
The Trustees discussed an application for funding entitled "Trends in and risk factors for drug-resistant tubereculosis in South African gold miners" at their Meetinng in November 2007. Following further discussions and a meeting with members of the research team, it was agreed to fund this work over one year at a cost of £89,984. Dr Clare van Halsema, who was based in South Africa for the duration of this work, and Dr Alison Grant, based at the LSH&TM, were the leading members of the team. Work commenced in April 2008. A six-month extension to the grant was agreed by the Trustees in March 2009, and the work was completed in September 2009. Dr Alison Grant can be contacted on firstname.lastname@example.org
An application was considered in November 2007 for a study into the Genotoxicity of single walled carbon nanotubes to be carried out by Dr Shareen Doak and Dr Chris Wright at Swansea University, and the Trustees agreed to fund this eighteen-month study at a cost of £80,342. The work is intended to allow the researchers to determine the impact of single-walled carbon nanotubes upon genetic integrity, providing valuable data for future exposure risk-assessment. Dr Doak can be contacted on S.H.Doak@swansea.ac.uk
University of Central Lancashire
An application was considered and approved in November 2007 for work entitled "Mortality from lung cancer in the British cotton industry", to update a cohort study of some 3,500 workers in the British cotton industry and carry out an analysis of the risks of lung and other cancers. The updated data from this study will contribute to a large multi-national pooled analysis of cotton workers which is expected to be co-ordinated by the WHO International Agency for Research on Cancer. The study was led by Professor Damien McElvenny, with Professor David Coggon at the MRC Lifecourse Epidemiology Unit in Southampton, and Professor Dick Heederik from the Institute of Risk Assessment Science at the University of Utrecht.
University of Edinburgh
A grant was awarded to Dr Simon Brown, Professor Bill MacNee and Professor Ken Donaldson for a twelve-month pilot study into the use of zebrafish as a model for nanoparticle technology. Dr Brown can be contacted on email@example.com
University of Edinburgh/Professor Ken Donaldson
The Trustees agreed to fund a further ten year Colt Foundation Professorial Fellowship for Professor Ken Donaldson, to enable him to remain on a full-time basis in the University's ELEGI/Colt Research Laboratories within the Centre for Inflammation Research in the Medical School. This Fellowship commenced in 2007. Professor Donaldson can be contacted on firstname.lastname@example.org
University of Aberdeen
A grant was awarded for a study entitled "Workplace health surveillance for occupational skin diseases - diagnostic accuracy and reliability of a teledermatology tool". The work was led by Dr Finlay Dick, with Dr Markus Steiner, Dr Sean Semple, Professor Jon Ayres, and Dr Anthony Ormerod, and was completed in 2009. Dr Steiner submiitted his PhD based on this work in 2012.
University of Southampton
At the Trustees' Meeting in November 2005, a grant of £64,650 was awarded to Professor David Coggon at the MRC Lifecourse Epidemiology Unit for a study entitled "Cross-cultural study of musculo-skeletal and other somatic symptoms and associated disability". A further grant to continue this work with a four year international collaborative study was also agreed in principle, subject only to receipt of satisfactory individual proposals from the various countries concerned. Professor Coggon can be contacted on email@example.com
University of Southampton
In November 2005, the Trustees agreed to fund a study led by Professor Keith Palmer at the MRC Lifecourse Epidemiology Unit entitled "Risk factors for Carpal Tunnel Syndrome and non-specific wrist-hand symptoms: Real differences or part of a continuum?". The study started in September 2006 and continued for a three year period at a cost of £135,167. Professor Palmer can be contacted on firstname.lastname@example.org
National Heart and Lung Institute with the Royal Brompton Hospital
Asthma afflicts about ten percent of children in Western Europe, a figure which continues to rise. Its causes are poorly understood and undoubtedly complex. In part the disease reflects early exposure to allergens in the home, but this is probably not sufficient cause. The aim of the study was to examine which factors - environmental, infective and genetic - modify the role of allergen exposure in the development of the disease. The Foundation supported this project, based in Ashford in Kent, from 1993, initially with a grant of £389,000 over five years, followed by subsequent grants to continue the work into 2007. The team was led by Professor Sir Anthony Newman Taylor.
Parallel studies - using the Colt protocol developed in Ashford - then took place in Barcelona (Josep-Maria Anto), Menorca (Matias Torrent) and Munich (Erika von Mutius). In this way it will be possible to make comparisons with the Ashford findings, under quite different environmental conditions.
Further information can be obtained from Professor Paul Cullinan on email@example.com and the website for this project is www.asthmainashford.co.uk